ea0044p211 | Reproduction | SFEBES2016
Owens Lisa
, Lerner Avi
, Sposini Silvia
, Christopoulos George
, Khanjani Shiran
, Islam Razia
, Lavery Stuart
, Tsui Vicky
, Hardy Kate
, Franks Stephen
, Hanyaloglu Aylin
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 510% of women of reproductive age, and is the major cause of anovulatory infertility. Aberrant secretion and/or action of gonadotropins are implicated but, to date, we have only limited knowledge about the precise mechanisms involved. Recent genome wide association studies have discovered signals at loci close to the genes coding for gonadotropin receptors. The functional significanc...